Abstract
Omnipresent bioelectrical events known as slow waves are responsible for coordinating motility in the gastrointestinal tract. Functional motility diseases, such as gastroparesis, are associated with slow wave dysrhythmias. Electrical stimulation is a potential therapy to correct abnormal slow wave patterns. We present the design and application of a new gastric pacemaker. Real-time changes to the stimulation parameters such as period, amplitude and pulse width were applied using a graphical user interface, which communicated with the microcontroller to deliver the stimulus. The new pacemaker allows the voltage, delivered current and resistance between pacing electrodes to be continuously monitored. The pacing device was applied experimentally and was able to modulate and entrain gastric slow wave activity. After the onset of pacing, the direction of slow wave propagation was altered. Furthermore, the mean velocity and amplitude of slow wave activity increased from 4.7 +/- 1.5 to 5.4 +/- 1.3 mm/s, and from 1.1 +/- 1.1 to 1.7 +/- 0.9 mV, respectively. A simplified bidomain electrical model was used to simulate the recorded stimulus artifact. The model illustrated a new approach to evaluate if the stimulus has been delivered to the gastric tissue. The new pacing device and model will be used to investigate the mechanisms that allow pacing to entrain slow wave activity.